Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Sep;597(17):4427-4428.
doi: 10.1113/JP278461. Epub 2019 Aug 6.

Rebuttal from Alex J. Smith and Alan S. Verkman

Affiliations
Comment

Rebuttal from Alex J. Smith and Alan S. Verkman

Alex J Smith et al. J Physiol. 2019 Sep.
No abstract available

Keywords: aquaporin-4; csf; glymphatic system.

PubMed Disclaimer

Conflict of interest statement

Author Conflict: No competing interests declared

Comment on

References

    1. Bedussi B, Almasian M, de Vos J, VanBavel E & Bakker EN (2018). Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow. J Cereb Blood Flow Metab 38, 719–726 - PMC - PubMed
    1. Iliff JJ & Simon MA (2019) The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4 J Physiol xxx - PMC - PubMed
    1. Jin BJ, Smith AJ & Verkman AS (2016). Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism. J Gen Physiol 148, 489–501 - PMC - PubMed
    1. Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Pla V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ & Nedergaard M (2018). Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife 7, e40070. - PMC - PubMed
    1. Papadopoulos MC, Manley GT, Krishna S & Verkman AS (2004). Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18, 1291–1293. - PubMed

Publication types