CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4

Jeffrey Iliff^{1

2

3}, Matthew Simon⁴

Affiliations

¹ VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
² Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
³ Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
⁴ Neuroscience Graduate Program, Oregon Health & Science University, Portland, OR, USA.

Jeffrey Iliff et al. J Physiol. 2019 Sep.

. 2019 Sep;597(17):4417-4419.

doi: 10.1113/JP277635. Epub 2019 Aug 6.

Jeffrey Iliff^{1

2

3}, Matthew Simon⁴

¹ VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
² Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
³ Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
⁴ Neuroscience Graduate Program, Oregon Health & Science University, Portland, OR, USA.

No abstract available

Keywords: aqp4; astrocytic; bulk flow; glymphatic.

Comment in

Rebuttal from Alex J. Smith and Alan S. Verkman.
Smith AJ, Verkman AS. Smith AJ, et al. J Physiol. 2019 Sep;597(17):4427-4428. doi: 10.1113/JP278461. Epub 2019 Aug 6. J Physiol. 2019. PMID: 31389015 Free PMC article. No abstract available.

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