Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct;63(20):e1900149.
doi: 10.1002/mnfr.201900149. Epub 2019 Aug 26.

Protective Effects of Anthocyanins in Obesity-Associated Inflammation and Changes in Gut Microbiome

Shasika Jayarathne  1   2   3 , April J Stull  4 , Oak-Hee Park  1   2   3 , Jung Han Kim  5 , Leslie Thompson  3   6 , Naima Moustaid-Moussa  1   2   3
Affiliations
Review

Protective Effects of Anthocyanins in Obesity-Associated Inflammation and Changes in Gut Microbiome

Shasika Jayarathne et al. Mol Nutr Food Res. 2019 Oct.

Abstract

Obesity is a complex disease and a major public health epidemic. Chronic, low-grade inflammation is a common underlying feature of obesity and associated metabolic diseases; adipose tissue is a major contributor to this systemic inflammation. Evidence shows that obesity-associated inflammation may originate from gut dysfunction, including changes in intestinal bacteria or microbiome profiles. Increasingly, food and plant bioactive compounds with antioxidant and anti-inflammatory properties are proposed to ameliorate obesity-associated inflammation. Among these, the health-promoting effects of anthocyanin-rich foods are of interest here. Specifically, this review summarizes the reported benefits of anthocyanins in obesity-associated inflammation and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocyanins both in vivo and in vitro.

Keywords: adipose tissue; anthocyanins; inflammation; microbiota; obesity.

PubMed Disclaimer

References

    1. J. I. Lakkis, M. R. Weir, Prog. Cardiovasc. Dis. 2018, 61, 157.
    1. WHO. Obesity and overweight, http://www.who.int/mediacentre/factsheets/fs311/en/ (accessed: June 2016).
    1. C. L. Ogden, M. D. Carroll, H. G. Lawman, C. D. Fryar, D. Kruszon-Moran, B. K. Kit, K. M. Flegal, JAMA, J. Am. Med. Assoc. 2016, 315, 2292.
    1. H. Tilg, A. R. Moschen, Mol. Med. 2008, 14, 222.
    1. N. S. Kalupahana, K. J. Claycombe, N. Moustaid-Moussa, Adv. Nutr. 2011, 2, 304.

Publication types

LinkOut - more resources