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. 1988 Mar;70(3):391-4.
doi: 10.1016/0300-9084(88)90212-x.

Misaminoacylation and transamidation are required for protein biosynthesis in Lactobacillus bulgaricus

A Schön  1 , H Hottinger, D Söll
Affiliations
Free article

Misaminoacylation and transamidation are required for protein biosynthesis in Lactobacillus bulgaricus

A Schön et al. Biochimie. 1988 Mar.
Free article

Abstract

Aminoacylation studies with Lactobacillus bulgaricus show that this organism possesses glutamyl-tRNA synthetase activity; however, glutamyl-tRNA synthetase activity cannot be demonstrated. Instead, Glu-tRNAGln, which is formed by glutamyl-tRNA synthetase, is amidated by a specific amidotransferase to Gln-tRNAGln. The amide donor in this reaction is glutamine. Thus, Gln-tRNAGln in this organism is not formed by direct glutaminylation of tRNAGln, but instead by a pathway which involves misaminoacylation and transamidation.

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