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Review
. 2019 Jun 26:9:53.
doi: 10.1186/s13578-019-0314-y. eCollection 2019.

The single-cell sequencing: new developments and medical applications

Xiaoning Tang #  1   2 , Yongmei Huang #  1   2 , Jinli Lei  1   2 , Hui Luo  1   2 , Xiao Zhu  1   2
Affiliations
Review

The single-cell sequencing: new developments and medical applications

Xiaoning Tang et al. Cell Biosci. .

Abstract

Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single-cell sequencing technologies and their applications in oncology, microbiology, neurology, reproduction, immunology, digestive and urinary systems, highlighting the important role that single-cell sequencing techniques play in these areas.

Keywords: Cancer; Clinical applications; Developments; Immunology; Single-cell sequencing technologies; Transcriptome.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The principle of single-cell sequencing. It is a process of isolating a single cell for sequencing and studying cell heterogeneity, molecular mapping, immune infiltration and epigenetic changes
Fig. 2
Fig. 2
The clinical applications of single-cell sequencing in different fields, like cancer, immune system, reproductive system, microorganisms, etc. These will help to clarify some of the problems and provide a basis for finding better treatments
See this image and copyright information in PMC

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