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Review
. 2019 Aug 2;14(1):1-4.
doi: 10.1002/cld.777. eCollection 2019 Jul.

Adenosinergic Signaling in Liver Fibrosis

Shilpa Tiwari-Heckler  1 , Z Gordon Jiang  1
Affiliations
Review

Adenosinergic Signaling in Liver Fibrosis

Shilpa Tiwari-Heckler et al. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
Signaling via extracellular purines and metabolites. ATP and adenosine diphosphate (ADP) are metabolized to AMP through CD39 family ectoenzymes. CD73 converts AMP to adenosine. Adenosine is irreversibly deaminated to inosine by the ectoenzyme ADA or transported back into the cell via ENT. Adenosine signaling is mediated via activation of four G protein‐coupled receptors.
Figure 2
Figure 2
Mechanism of adenosine in modulating liver fibrosis. Enhanced release of ATP during hepatocellular injury leads to an excess of adenosine in the hepatic extracellular milieu. Adenosine promotes liver fibrosis directly via activation of A2A receptors on HSCs leading to increased production of collagen fibers. Furthermore, adenosine signaling has an impact on the differentiation of macrophages by favoring the alternative activation via A2B receptors. Meanwhile, A2A receptor signaling inhibits the release of proinflammatory cytokines.
See this image and copyright information in PMC

References

    1. Arnesen E, Huseby NE, Brenn T, et al. The Tromso Heart Study: Distribution of, and determinants for, gamma‐glutamyltransferase in a free‐living population. Scand J Clin Lab Invest 1986;46:63‐70. - PubMed
    1. Torres DM, Harrison SA. Is it time to write a prescription for coffee? Coffee and liver disease. Gastroenterology 2013;144:670‐672. - PubMed
    1. Furtado KS, Prado MG, Aguiar ESMA, et al. Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats. Basic Clin Pharmacol Toxicol 2012;111:339‐347. - PubMed
    1. Eltzschig HK, Sitkovsky MV, Robson SC. Purinergic signaling during inflammation. N Engl J Med 2012;367:2322‐2333. - PMC - PubMed
    1. Luo F, Le NB, Mills T, et al. Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis. FASEB J 2016;30:874‐883. - PMC - PubMed