Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug 2;14(1):12-15.
doi: 10.1002/cld.807. eCollection 2019 Jul.

Obesity and Liver Decompensation

Affiliations
Review

Obesity and Liver Decompensation

Joseph C Ahn et al. Clin Liver Dis (Hoboken). .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Conceptual diagram of the pretransplant, peritransplant, and posttransplant challenges in the obese patient with liver transplant.
Figure 2
Figure 2
(A) Proportion of patients experiencing first clinical decompensation according to BMI group. Obesity was associated with a significantly higher proportion of clinical decompensation in a median follow‐up of 59 months. (B) Probability of first clinical decompensation of cirrhosis according to BMI group. As shown, obese patients had the highest probability of decompensation, and patients with a normal BMI had the lowest probability of decompensation, with overweight patients having an intermediate probability. Differences among groups were statistically significant (log‐rank 7.60; P = 0.022).

References

    1. Spengler EK, O’Leary JG, Te HS, et al. Liver transplantation in the obese cirrhotic patient. Transplantation 2017;101:2288‐2296. - PMC - PubMed
    1. Berzigotti A, Garcia‐Tsao G, Bosch J, et al. Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology 2011;54:555‐561. - PMC - PubMed
    1. Schlansky B, Naugler WE, Orloff SL, et al. Higher mortality and survival benefit in obese patients awaiting liver transplantation. Transplantation 2016;100:2648‐2655. - PubMed
    1. Sundaram V, Kaung A, Rajaram A, et al. Obesity is independently associated with infection in hospitalized patients with end‐stage liver disease. Aliment Pharmacol Ther 2015;42:1271‐1280. - PubMed
    1. Sundaram V, Jalan R, Ahn JC, et al. Class III obesity is a risk factor for the development of acute‐on‐chronic liver failure in patients with decompensated cirrhosis. J Hepatol 2018;69:617‐625. - PubMed