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Review
. 2019 Aug;10(4):789-796.
doi: 10.21037/jgo.2019.02.14.

MicroRNA-122 in patients with hepatitis B and hepatitis B virus-associated hepatocellular carcinoma

Mohammad Reza Mahmoudian-Sani  1 , Samira Asgharzade  2 , Arash Alghasi  1 , Ali Saeedi-Boroujeni  3 , Seyed Jafar Adnani Sadati  4 , Mohammad Taghi Moradi  5
Affiliations
Review

MicroRNA-122 in patients with hepatitis B and hepatitis B virus-associated hepatocellular carcinoma

Mohammad Reza Mahmoudian-Sani et al. J Gastrointest Oncol. 2019 Aug.

Abstract

Hepatitis B virus (HBV) infection is known as a serious problem in the domain of public health and approximately 350 million people across the world are affected with this infectious disease. As well, microRNAs are recognized as a type of small non-coding RNAs that can be widely used as a diagnostic biomarker and prognosis method of special diseases. In this respect, microRNA-122 or miR-122 can play a significant role in the pathogenesis of several hepatic diseases. Given the importance of microRNA-122 in the liver as well as its pathology, this study focused on the potential functions of microRNA-122 in pathogenesis, diagnosis, and treatment of HBV infection. In this regard, the findings of previous studies had indicated that expression of microRNA-122 in patients with HBV infection could be significantly deregulated. The results of this study were consistent with the idea that diagnosis and treatment of this infectious disease using microRNA-122 could be an efficient method.

Keywords: Hepatitis B virus (HBV); biomarker; hepatocellular carcinoma (HCC); microRNA-122.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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