Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct 10;238(2):249-52.
doi: 10.1016/0014-5793(88)80489-7.

Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells

I Komuro  1 , H Kurihara, T Sugiyama, M Yoshizumi, F Takaku, Y Yazaki
Affiliations
Free article

Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells

I Komuro et al. FEBS Lett. .
Free article

Erratum in

  • FEBS Lett 1989 Feb 27;244(2):509

Abstract

Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.

PubMed Disclaimer

Publication types

LinkOut - more resources