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. 2019 Nov;112(5):930-938.e1.
doi: 10.1016/j.fertnstert.2019.06.018. Epub 2019 Aug 5.

Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety

Snigdha Alur-Gupta  1 , Anat Chemerinski  2 , Chang Liu  3 , Jenna Lipson  4 , Kelly Allison  5 , Mary D Sammel  6 , Anuja Dokras  2
Affiliations

Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety

Snigdha Alur-Gupta et al. Fertil Steril. 2019 Nov.

Abstract

Objective: To evaluate differences in body-image distress (BID) scores between women with polycystic ovary syndrome (PCOS) and controls and whether BID mediates anxiety and depression.

Design: Cross-sectional study.

Setting: Academic institution.

Patient(s): Reproductive-aged women with PCOS (n = 189) and controls (n = 225).

Intervention: Administering the Multidimensional Body-Self Relations-Appearance Subscale (MBSRQ-AS), Stunkard Figure Rating Scale (FRS), Hospital Anxiety and Depression Scale (HADS), and PCOS quality of life survey (MPCOS-Q).

Main outcome measure(s): BID, depression, and anxiety scores and mediation of depression and anxiety scores by BID.

Result(s): Women with PCOS had worse BID scores on all five MBSRQ-AS subscales adjusted for age, body mass index, race, pregnancy history, income, and employment, and larger differences on the FRS compared with the control women. In multivariable regression models, the prevalence of depressive (28% vs. 19.2%) and anxiety (76.5% vs. 56.5%) symptoms were also statistically significantly higher in women with PCOS compared with the controls. Most MBSRQ-AS subscale scores statistically significantly correlated with depression, anxiety, and quality of life scores. The association between PCOS/control status and higher anxiety and depression scores was completely mediated by the appearance evaluation and body areas satisfaction subscales and partially mediated by overweight preoccupation, appearance orientation, and self-classified weight.

Conclusion(s): Women with PCOS have increased BID and depressive and anxiety symptoms. In our study different aspects of BID either fully or partially mediated the association between PCOS/control status and depression and anxiety scores, suggesting that therapeutic interventions targeted at improving body image may decrease depressive and anxiety symptoms.

Keywords: Anxiety; PCOS; body image distress; depression; quality of life.

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Figures

Figure 1A:
Figure 1A:
Mediation analysis framework
Figure 1B:
Figure 1B:
Path C: Mean depression score (HADS) differences between the PCOS and control groups before and after accounting for mediation by BID subscales. formula image
Figure 1C:
Figure 1C:
Path C: Mean anxiety score (HADS) differences between the PCOS and control groups before and after accounting for mediation by BID subscales. formula image
See this image and copyright information in PMC

Comment in

References

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