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Comment
. 2019 Sep 2;151(9):1061.
doi: 10.1085/jgp.201912458. Epub 2019 Aug 8.

How myosin II achieves total shutdown

Ben Short
Comment

How myosin II achieves total shutdown

Ben Short. J Gen Physiol. .

Abstract

JGP study describes 3-D structure of the 10S form of myosin II, identifying key interactions between the head and tail domains that keep the motor protein switched off.

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Figures

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Left to right: Roger Craig, Kyoung Hwan Lee, Shixin Yang, and colleagues generate a 3-D reconstruction of the 10S conformation of myosin II that explains how interactions between the tail and head domains help to completely switch off the protein’s motor activity. Key interactions include TB3, which inhibits the ATPase activity of the “blocked” head, and TF1, which masks the actin-binding domain of the “free” head.
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References

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