Dosing time matters

Marc D Ruben¹, David F Smith^{2

3}, Garret A FitzGerald^{4

5

6}, John B Hogenesch⁷

Affiliations

¹ Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.
² Divisions of Pediatric Otolaryngology and Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
³ Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
⁴ Department of Systems Pharmacology and Translational Therapeutics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. garret@upenn.edu john.hogenesch@cchmc.org.
⁵ Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁶ Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁷ Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA. garret@upenn.edu john.hogenesch@cchmc.org.

Marc D Ruben et al. Science. 2019.

. 2019 Aug 9;365(6453):547-549.

doi: 10.1126/science.aax7621.

Marc D Ruben¹, David F Smith^{2

3}, Garret A FitzGerald^{4

5

6}, John B Hogenesch⁷

¹ Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.
² Divisions of Pediatric Otolaryngology and Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
³ Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
⁴ Department of Systems Pharmacology and Translational Therapeutics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. garret@upenn.edu john.hogenesch@cchmc.org.
⁵ Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁶ Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁷ Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA. garret@upenn.edu john.hogenesch@cchmc.org.

No abstract available

Figures

1. Hamprecht B, Nüssler C, Lynen F, FEBS Lett 4, 117 (1969). - PubMed
1. Lévi FA et al. , J. Natl. Cancer Inst 86, 1608 (1994). - PubMed
1. D’Alonzo GE et al. , Chest 107, 406 (1995). - PubMed
1. Hendel J, Hendel L, Aggestrup S, Aliment. Pharmacol. Ther 9, 693 (1995). - PubMed
1. Takahashi JS, Nat. Rev. Genet 18, 164 (2017). - PMC - PubMed