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Review
. 2019 Jul 23:10:494.
doi: 10.3389/fendo.2019.00494. eCollection 2019.

Modulatory Effects of Plant Polyphenols on Bone Remodeling: A Prospective View From the Bench to Bedside

Vanessa Nicolin  1 , Nunziatina De Tommasi  2 , Stefania Lucia Nori  2 , Fulvia Costantinides  3 , Federico Berton  3 , Roberto Di Lenarda  1
Affiliations
Review

Modulatory Effects of Plant Polyphenols on Bone Remodeling: A Prospective View From the Bench to Bedside

Vanessa Nicolin et al. Front Endocrinol (Lausanne). .

Abstract

During the past, a more comprehensive knowledge of mechanisms implicated in bone resorption processes has driven researchers to develop a compound library of many small molecules that specifically interfere with the genesis of osteoclast precursors cells. Natural compounds that suppress osteoclast commitment may have therapeutic value in treating pathologies associated with bone resorption like osteoporosis, rheumatoid arthritis, bone metastasis, and periodontal disease. The present review is focused on the current knowledge on the polyphenols derived from plants that could be efficacious in suppressing osteoclast differentiation and bone resorption.

Keywords: biomolecules; bone remodeling; coating surfaces; polyflavonoids; titanium implant.

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Figures

Figure 1
Figure 1
Schematic pathway illustrating the action of polyphenols on bone remodeling.
Figure 2
Figure 2
(A) Structures of main green tea polyphenols. (B) Quercitrin. (C) Taxifolin.
Figure 3
Figure 3
Structures of main anthocyanins.
Figure 4
Figure 4
Structures of phloridzin (A), oleuropien (B), and resveratrol (C).
Figure 5
Figure 5
Structure of 3,5,6,7,8,3,4-Heptamethoxyflavone.
See this image and copyright information in PMC

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