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. 2019 Dec;14(12):2093-2094.
doi: 10.4103/1673-5374.262585.

Interaction between cannabinoid and nucleotide systems as a new mechanism of signaling in retinal cell death

Hércules R Freitas  1 , Ricardo A M Reis  2 , Ana L M Ventura  3 , Guilherme R França  4
Affiliations

Interaction between cannabinoid and nucleotide systems as a new mechanism of signaling in retinal cell death

Hércules R Freitas et al. Neural Regen Res. 2019 Dec.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Hypothetical schematic image of the retinal cell death induced by cannabinoids and nucleotides. Retinal diseases promote ATP release, activating P2X7 receptors and inducing an increase in intracellular calcium (Ventura et al., 2018). The increase in calcium levels activates DAGL at the same time that inhibits MAGL activity, resulting in an increase of endocannabinoid levels at the extracellular medium. Endocannabinoids, in turn, activate CB1 and CB2 receptors and prime P2X7 receptors, triggering calcium entry in the cell. Sustained activation of P2X7 receptors can also promote mitochondrial stress, calcium shifts, fluorescent dye uptake and retinal cell death (Freitas et al., 2019). AEA: Anandamide; RD: retinal diseases; AMD: age-related macular degeneration; 2-AG: 2-arachidonoylglycerol; DAGL: diacylglycerol lipase; MAGL: monoacylglycerol lipase.
See this image and copyright information in PMC

References

    1. Chen Y, Luo X, Liu S, Shen Y. Neuroprotective effect of cannabinoid receptor 1 antagonist in the MNU-induced retinal degeneration model. Exp Eye Res. 2018;167:145–151. - PubMed
    1. El-Remessy AB, Rajesh M, Mukhopadhyay P, Horvath B, Patel V, Al-Gayyar MM, Pillai BA, Pacher P. Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line. Diabetologia. 2011;54:1567–1578. - PMC - PubMed
    1. Freitas HR, Isaac AR, Silva TM, Diniz GOF, Dos Santos Dabdab Y, Bockmann EC, Guimarães MZP, da Costa Calaza K, de Mello FG, Ventura ALM, de Melo Reis RA, França GR. Cannabinoids induce cell death and promote P2X7 receptor signaling in retinal glial progenitors in culture. Mol Neurobiol. 2019 doi:101007/s12035-019-1537-y. - PubMed
    1. Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells. Sci Rep. 2017;7:16169. - PMC - PubMed
    1. Imamura T, Tsuruma K, Inoue Y, Otsuka T, Ohno Y, Ogami S, Yamane S, Shimazawa M, Hara H. Rimonabant, a selective cannabinoid1 receptor antagonist, protects against light-induced retinal degeneration in vitro and in vivo. Eur J Pharmacol. 2017;803:78–83. - PubMed