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. 2019 Oct 1;58(40):14189-14192.
doi: 10.1002/anie.201908511. Epub 2019 Aug 30.

A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation

Daniel J Norman  1 , Alessia Gambardella  1 , Andrew R Mount  1 , Alan F Murray  2 , Mark Bradley  1
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A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation

Daniel J Norman et al. Angew Chem Int Ed Engl. .

Abstract

A ruthenium-based mitochondrial-targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of PtIV prodrugs into their active PtII counterparts, and drives the generation of singlet oxygen was designed. This dual mode of action drives two orthogonal cancer-cell killing mechanisms with temporal and spatial control. The designed photosensitiser was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin-resistance.

Keywords: anti-tumour agents; cancer; photocatalysis; platinum; prodrugs.

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