Comment
doi: 10.1016/j.molcel.2019.07.012.
REV1-POL ζ Inhibition and Cancer Therapy
Affiliations
- PMID: 31398321
- DOI: 10.1016/j.molcel.2019.07.012
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Comment
REV1-POL ζ Inhibition and Cancer Therapy
Mol Cell.
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Abstract
In a recent issue of Cell, Wojtaszek et al. (2019) reported a small-molecule inhibitor of mutagenic translesion DNA synthesis, which targets the interaction between REV1 and REV7, sensitizes cancer cells to cisplatin in vitro and in vivo, and reduces mutagenesis.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.Cell. 2019 Jun 27;178(1):152-159.e11. doi: 10.1016/j.cell.2019.05.028. Epub 2019 Jun 6. Cell. 2019. PMID: 31178121 Free PMC article.