HTLV-1 infection in solid organ transplant donors and recipients in Spain

doi:10.1186/s12879-019-4346-z

. 2019 Aug 9;19(1):706.

doi: 10.1186/s12879-019-4346-z.

HTLV-1 infection in solid organ transplant donors and recipients in Spain

Collaborators, Affiliations

Collaborators

Spanish HTLV Network:
C Rodríguez, M Vera, J Del Romero, G Marcaida, M D Ocete, E Caballero, I Molina, A Aguilera, J J Rodríguez-Calviño, D Navarro, C Rivero, M D Vilariño, R Benito, S Algarate, J Gil, R Ortiz de Lejarazu, S Rojo, J M Eirós, A San Miguel, C Manzardo, J M Miró, J García, I Paz, E Poveda, E Calderón, D Escudero, M Trigo, J Diz, M García-Campello, M Rodríguez Iglesias, A Hernández Betancor, A M Martín, J M Ramos, A Gimeno, F Gutiérrez, J C Rodríguez, V Sánchez, C Gómez Hernando, G Cilla, E Pérez Trallero, J López Aldeguer, L Fernández Pereira, J Niubó, M Hernández, A M López Lirola, J L Gómez Sirvent, L Force, C Cifuentes, S Pérez, L Morano, C Raya, A González Praetorius, J L Pérez, M Peñaranda, S Hernáez Crespo, J M Montejo, L Roc, A Martínez Sapiña, I Viciana, T Cabezas, A Lozano, J M Fernández, I García-Bermejo, G Gaspar, R García, M Górgolas, C Vegas, J Blas, P Miralles, M Valeiro, T Aldamiz, N Margall, C Guardia, E do Pico, I Polo, A Aguinaga, C Ezpeleta, S Sauleda, M Pirón, R González, L Barea, A Jiménez, L Blanco, A Suárez, I Rodríguez Avial, A Pérez Rivilla, P Parra, M Fernández, M Fernández Alonso, A Treviño, S Requena, L Benítez Gutiérrez, V Cuervas Mons, C de Mendoza, P Barreiro, V Soriano, O Corral, F Gómez-Gallego

Affiliations

¹ Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
² Universidad CEU-San Pablo, Madrid, Spain.
³ Hospital Miguel Servet, Zaragoza, Spain.
⁴ Hospital Lozano Blesa, Zaragoza, Spain.
⁵ Clínica Universitaria de Navarra, Pamplona, Spain.
⁶ Hospital General Universitario, Alicante, Spain.
⁷ Complejo Hospitalario, Toledo, Spain.
⁸ Hospital Conxo-CHUS, Santiago, Spain.
⁹ Hospital Puerta del Mar, Cádiz, Spain.
¹⁰ Complejo Hospitalario Universitario, Ourense, Spain.
¹¹ UNIR Health Sciences School and Medical Centre, Calle Almansa 101, 28040, Madrid, Spain. vicente.soriano@unir.net.

PMID: 31399112
PMCID: PMC6688206
DOI: 10.1186/s12879-019-4346-z

HTLV-1 infection in solid organ transplant donors and recipients in Spain

Carmen de Mendoza et al. BMC Infect Dis. 2019.

. 2019 Aug 9;19(1):706.

doi: 10.1186/s12879-019-4346-z.

Authors

Collaborators

Spanish HTLV Network:
C Rodríguez, M Vera, J Del Romero, G Marcaida, M D Ocete, E Caballero, I Molina, A Aguilera, J J Rodríguez-Calviño, D Navarro, C Rivero, M D Vilariño, R Benito, S Algarate, J Gil, R Ortiz de Lejarazu, S Rojo, J M Eirós, A San Miguel, C Manzardo, J M Miró, J García, I Paz, E Poveda, E Calderón, D Escudero, M Trigo, J Diz, M García-Campello, M Rodríguez Iglesias, A Hernández Betancor, A M Martín, J M Ramos, A Gimeno, F Gutiérrez, J C Rodríguez, V Sánchez, C Gómez Hernando, G Cilla, E Pérez Trallero, J López Aldeguer, L Fernández Pereira, J Niubó, M Hernández, A M López Lirola, J L Gómez Sirvent, L Force, C Cifuentes, S Pérez, L Morano, C Raya, A González Praetorius, J L Pérez, M Peñaranda, S Hernáez Crespo, J M Montejo, L Roc, A Martínez Sapiña, I Viciana, T Cabezas, A Lozano, J M Fernández, I García-Bermejo, G Gaspar, R García, M Górgolas, C Vegas, J Blas, P Miralles, M Valeiro, T Aldamiz, N Margall, C Guardia, E do Pico, I Polo, A Aguinaga, C Ezpeleta, S Sauleda, M Pirón, R González, L Barea, A Jiménez, L Blanco, A Suárez, I Rodríguez Avial, A Pérez Rivilla, P Parra, M Fernández, M Fernández Alonso, A Treviño, S Requena, L Benítez Gutiérrez, V Cuervas Mons, C de Mendoza, P Barreiro, V Soriano, O Corral, F Gómez-Gallego

Affiliations

¹ Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
² Universidad CEU-San Pablo, Madrid, Spain.
³ Hospital Miguel Servet, Zaragoza, Spain.
⁴ Hospital Lozano Blesa, Zaragoza, Spain.
⁵ Clínica Universitaria de Navarra, Pamplona, Spain.
⁶ Hospital General Universitario, Alicante, Spain.
⁷ Complejo Hospitalario, Toledo, Spain.
⁸ Hospital Conxo-CHUS, Santiago, Spain.
⁹ Hospital Puerta del Mar, Cádiz, Spain.
¹⁰ Complejo Hospitalario Universitario, Ourense, Spain.
¹¹ UNIR Health Sciences School and Medical Centre, Calle Almansa 101, 28040, Madrid, Spain. vicente.soriano@unir.net.

PMID: 31399112
PMCID: PMC6688206
DOI: 10.1186/s12879-019-4346-z

Abstract

Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain.

Methods: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008.

Results: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic.

Conclusion: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy.

Keywords: Adult T-cell leukaemia; HTLV-1; Immunosuppression; Screening; Transplantation; Tropical spastic paraparesis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Cited by

The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil.
Ishak R, de Oliveira Guimarães Ishak M, Vallinoto ACR. Ishak R, et al. Retrovirology. 2020 Feb 14;17(1):4. doi: 10.1186/s12977-020-0512-z. Retrovirology. 2020. PMID: 32059740 Free PMC article. Review.
Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014-2021.
Letafati A, Mozhgani SH, Norouzi M, Aboofazeli A, Taghiabadi Z, Zafarian N, Seyedi S, Jaberi EM, Poursaleh S, Karami M, Sarrafzadeh S, Sadeghi A. Letafati A, et al. Retrovirology. 2024 Dec 17;21(1):22. doi: 10.1186/s12977-024-00656-9. Retrovirology. 2024. PMID: 39690425 Free PMC article.
Donor-derived infections in solid organ transplant recipients.
Peghin M, Grossi PA. Peghin M, et al. Curr Opin Organ Transplant. 2023 Oct 1;28(5):384-390. doi: 10.1097/MOT.0000000000001094. Epub 2023 Aug 8. Curr Opin Organ Transplant. 2023. PMID: 37555801 Free PMC article. Review.
HTLV-1/2 Infection in Blood Donors from a Non-Endemic Area (Catalonia, Spain) between 2008 and 2017: A 10-Year Experience.
Piron M, Salvador F, Caballero E, Sánchez-Montalvá A, Bes M, Casamitjana N, Puig L, Molina I, Sauleda S. Piron M, et al. Viruses. 2022 Sep 6;14(9):1975. doi: 10.3390/v14091975. Viruses. 2022. PMID: 36146780 Free PMC article.
HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases.
Eusebio-Ponce E, Anguita E, Paulino-Ramirez R, Candel FJ. Eusebio-Ponce E, et al. Rev Esp Quimioter. 2019 Dec;32(6):485-496. Epub 2019 Oct 25. Rev Esp Quimioter. 2019. PMID: 31648512 Free PMC article. Review.

See all "Cited by" articles

References

1. Gessain A, Barin F, Vernant J, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2:407–410. doi: 10.1016/S0140-6736(85)92734-5. - DOI - PubMed
1. Yoshida M, Seiki M, Yamaguchi K, et al. Monoclonal integration of HTLV provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A. 1984;81:2534–2537. doi: 10.1073/pnas.81.8.2534. - DOI - PMC - PubMed
1. Taylor GP. Human T-lymphotropic virus type 1 infection and solid organ transplantation. Rev Med Virol. 2018;28:207–237. doi: 10.1002/rmv.1970. - DOI - PubMed
1. Gallo R, Willems L, Hasegawa H, global virus Network’s task force on HTLV-1 Screening transplant donors for HTLV-1 and -2. Blood. 2016;128:3029–3031. - PubMed
1. Boletin Oficial del Estado (BOE) 2014, November 5, pp. 90536–90538.

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

[1] Gessain A, Barin F, Vernant J, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2:407–410. doi: 10.1016/S0140-6736(85)92734-5. - DOI - PubMed

[2] Gessain A, Barin F, Vernant J, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2:407–410. doi: 10.1016/S0140-6736(85)92734-5. - DOI - PubMed

[3] Yoshida M, Seiki M, Yamaguchi K, et al. Monoclonal integration of HTLV provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A. 1984;81:2534–2537. doi: 10.1073/pnas.81.8.2534. - DOI - PMC - PubMed

[4] Yoshida M, Seiki M, Yamaguchi K, et al. Monoclonal integration of HTLV provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A. 1984;81:2534–2537. doi: 10.1073/pnas.81.8.2534. - DOI - PMC - PubMed

[5] Taylor GP. Human T-lymphotropic virus type 1 infection and solid organ transplantation. Rev Med Virol. 2018;28:207–237. doi: 10.1002/rmv.1970. - DOI - PubMed

[6] Taylor GP. Human T-lymphotropic virus type 1 infection and solid organ transplantation. Rev Med Virol. 2018;28:207–237. doi: 10.1002/rmv.1970. - DOI - PubMed

[7] Gallo R, Willems L, Hasegawa H, global virus Network’s task force on HTLV-1 Screening transplant donors for HTLV-1 and -2. Blood. 2016;128:3029–3031. - PubMed

[8] Gallo R, Willems L, Hasegawa H, global virus Network’s task force on HTLV-1 Screening transplant donors for HTLV-1 and -2. Blood. 2016;128:3029–3031. - PubMed

[9] Boletin Oficial del Estado (BOE) 2014, November 5, pp. 90536–90538.

[10] Boletin Oficial del Estado (BOE) 2014, November 5, pp. 90536–90538.

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

HTLV-1 infection in solid organ transplant donors and recipients in Spain

Collaborators

Affiliations

HTLV-1 infection in solid organ transplant donors and recipients in Spain

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Similar articles

Cited by

References

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical