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Review
. 2019 Aug 9;17(1):65.
doi: 10.1186/s12958-019-0511-x.

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Yubin Cao  1   2 , Zeping Li  1   2 , Wenyu Jiang  1   2 , Yan Ling  3 , Haibin Kuang  4   5
Affiliations
Review

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Yubin Cao et al. Reprod Biol Endocrinol. .

Abstract

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.

Keywords: KISS1R; Kisspeptin; Ovary; Placenta; Testis; Uterus.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The role of kisspeptin/KISS1R system in the ovary. Ovarian-derived kisspeptin regulates follicular development, oocyte maturation, and ovulation in autocrine or paracrine manner. a The possible role and mechanisms of kisspeptin in follicular development. b The possible role and mechanisms of kisspeptin in oocyte maturation. c The role and mechanisms of kisspeptin in ovulation. AMH, anti-Mullerian hormone; BDNF, brain-derived neurotrophic factor; BMP15, bone morphogenetic protein 15; COX-2, Cyclooxygenase-2; FSH, follicle stimulating hormone; FSHR, follicle stimulating hormone receptor; GDF9, growth differentiation factor 9; LH, luteinizing hormone; NA, noradrenaline; NTRK2, neurotrophic tyrosine kinase receptor type 2; PKC, protein kinase C
Fig. 2
Fig. 2
The potential role of kisspeptin/KISS1R system in the pregnancy. a A schematic diagram of zygote development, embryo implantation and fetal development in the uterus. b The known and potential mechanisms of locally produced kisspeptin in embryo implantation. c The known and potential mechanisms of peripheral kisspeptin in fetal development. HFA, human fetal adrenal; MMPs, matrix metalloproteinases; LIF, leukemia inhibitory factor; VEGFA, vascular endothelial growth factor A
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