Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Sep:47:14-15.
doi: 10.1016/j.ebiom.2019.08.005. Epub 2019 Aug 8.

Insights into deoxyribonucleoside therapy for mitochondrial TK2 deficient mtDNA depletion

Ann Saada  1
Affiliations
Comment

Insights into deoxyribonucleoside therapy for mitochondrial TK2 deficient mtDNA depletion

Ann Saada. EBioMedicine. 2019 Sep.
No abstract available

Keywords: Deoxyribonucleoside therapy; Mitochondria; Respiratory chain; Thymidine kinase TK2; mtDNA Depletion.

PubMed Disclaimer

Conflict of interest statement

The author declares no conflicts of interest.

Comment on

References

    1. Blázquez-Bermejo C., Molina-Granada D., Vila-Julià F., Jiménez-Heis D., Zhou X., Torres-Torronteras J. Age-related metabolic changes limit efficacy of deoxynucleoside based therapy in TK2-deficient mice. EBioMedicine. 2019 - PMC - PubMed
    1. Domínguez-González C., Madruga-Garrido M., Mavillard F., Garone C., Aguirre-Rodríguez F.J., Donati M.A. Deoxynucleoside therapy for thymidine kinase 2-deficient myopathy. Ann Neurol. 2019;86(2):293–303. - PMC - PubMed
    1. Lopez-Gomez C., Hewan H., Sierra C., Akman H.O., Sanchez-Quintero M.J., Juanola-Falagarona M. Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency. EBioMedicine. 2019 - PMC - PubMed
    1. Lopez-Gomez C., Levy R.J., Sanchez-Quintero M.J., Juanola-Falgarona M., Barca E., Garcia-Diaz B. Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency. Ann Neurol. 2017;81(5):641–652. - PMC - PubMed
    1. Moraes C.T., Shanske S., Tritschler H.J., Aprille J.R., Andreetta F., Bonilla E. mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am J Hum Genet. 1991;48(3):492–501. - PMC - PubMed