Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;114(7):762-768.
doi: 10.1111/vox.12834. Epub 2019 Aug 11.

Preoperative autologous blood donation in adult bone marrow donors: reappraisal of a single-centre experience

Luciana Teofili  1   2 , Caterina Giovanna Valentini  1 , Maria Bianchi  1 , Claudio Pellegrino  2 , Silvia Bellesi  1 , Patrizia Chiusolo  1   2 , Luca Laurenti  1   2 , Idanna Innocenti  1 , Valerio De Stefano  1   2 , Andrea Bacigalupo  1   2
Affiliations

Preoperative autologous blood donation in adult bone marrow donors: reappraisal of a single-centre experience

Luciana Teofili et al. Vox Sang. 2019 Oct.

Abstract

To avoid risk for allogeneic transfusions in healthy bone marrow (BM) donors, 1-2 preoperative autologous blood donations (PAD) are usually collected before the BM harvest. We analysed the haematological parameters in BM donors before and after the harvest, to assess the efficacy of this practice in limiting the postharvest anaemia. Overall, 102 consecutive donors underwent BM harvest preceded by one (26 cases) or two PAD (76 cases), which were infused during BM collection. We analysed the parameters related to donors, PAD timing and BM graft characteristics. PAD induced a significant decrease in Hb (from 14·6 g/dl, IQ range 13·3-15·5 to12·9 g/dl, IQ range 11·8-13·9; P < 0·0001) in all donors, with a median Hb loss at day -1 of 10·9% (IQ range 6·8-14·2). The PAD-related Hb decrease was independent of sex or number of PAD, and was inversely related to the time elapsed from first or last PAD. In comparison with values recorded at day-1, BM harvest produced an additional Hb decrease, accounting for a median Hb loss of 18·9% (IQ range 14·9-24·4). Overall, in comparison with pre-PAD values, Hb levels at day +1 were reduced of 28·9% (IQ range 23·6-32·2), independently if donors had 1 or 2 PAD reinfused. In conclusion, these data show that two PAD do not carry any advantage over one PAD. An eventual benefit of PAD can be achieved only if an adequate interval between PAD and BM harvest elapses. Prospective randomized studies could be worth to establish if any role for PAD does exist in BM donors.

Keywords: anaemia; bone marrow harvest; perioperative blood donation.

PubMed Disclaimer

References

    1. Miller JP, Perry EH, Price TH, et al.: Recovery and safety profiles of marrow and PBSC donors: experience of the National Marrow Donor Program. Biol Blood Marrow Transplant. 2008; 14(9 Suppl):29-36
    1. Gandini A, Roata C, Franchini M, et al.: Unrelated allogeneic bone marrow donation: short- and long-term follow-up of 103 consecutive volunteer donors. Bone Marrow Transplant. 2001; 28:369-74
    1. Stroncek DF, Holland PV, Bartch G, et al.: Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program. Blood 1993; 81:1940-6
    1. Rowley SD, Donaldson G, Lilleby K, et al: Experiences of donors enrolled in a randomized study of allogeneic bone marrow or peripheral blood stem cell transplantation. Blood 2001; 97:2541-8
    1. DECRETO 2 novembre 2015. Disposizioni relative ai requisiti di qualita' e sicurezza del sangue e degli emocomponenti. (15A09709) (GU Serie Generale n.300 del 28-12-2015 - Suppl. Ordinario n. 69)

LinkOut - more resources