Definition of bleeding events in studies evaluating prophylactic antithrombotic therapy in pregnant women: A systematic review and a proposal from the ISTH SSC

Bernard Tardy¹, Emilie Chalayer¹, Pieter Willem Kamphuisen², Fionnuala Ni Ainle³, Peter Verhamme⁴, Marie Noelle Varlet⁵, Celine Chauleur⁵, Marc Rodger⁶, Adel Merah¹, Andrea Buchmuller^{1

7

8

9}, Ingrid Bistervels¹⁰, Maria T De Sancho¹¹, Saskia Middeldorp¹⁰, Laurent Bertoletti^{1

7

8

9}; SSC Subcommittee on Control of Anticoagulation of the ISTH

Affiliations

¹ Inserm CIC 1408, FCRIN-INNOVTE, CHU de Saint Etienne, Saint Etienne, France.
² Department of Internal Medicine, Tergooi Hospital, Hilversum, the Netherlands.
³ Department of Haematology, Mater Misericordiae University Hospital Dublin, Dublin, Ireland.
⁴ Vascular Medicine and Haemostasis, University of Leuven, Leuven, Belgium.
⁵ Department of Gynecology and Obstetrics, University Hospital, Saint-Étienne, University Jean-Monnet, Saint-Étienne, France.
⁶ Department of Medicine, Division of Hematology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
⁷ Service de Médecine Vasculaire et Thérapeutique, CHU de St-Etienne, St-Etienne, France.
⁸ INSERM, UMR1059, Equipe Dysfonction Vasculaire et Hémostase, Université Jean-Monnet, St-Etienne, France.
⁹ FCRIN-INNOVTE, St-Etienne, France.
¹⁰ Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
¹¹ Department of Medicine, Division of Hematology-Oncology, New York Presbyterian Hospital of Weill Cornell Medical College, New York, NY, USA.

Free article

Bernard Tardy et al. J Thromb Haemost. 2019 Nov.

Free article

. 2019 Nov;17(11):1979-1988.

doi: 10.1111/jth.14576. Epub 2019 Aug 12.

¹ Inserm CIC 1408, FCRIN-INNOVTE, CHU de Saint Etienne, Saint Etienne, France.
² Department of Internal Medicine, Tergooi Hospital, Hilversum, the Netherlands.
³ Department of Haematology, Mater Misericordiae University Hospital Dublin, Dublin, Ireland.
⁴ Vascular Medicine and Haemostasis, University of Leuven, Leuven, Belgium.
⁵ Department of Gynecology and Obstetrics, University Hospital, Saint-Étienne, University Jean-Monnet, Saint-Étienne, France.
⁶ Department of Medicine, Division of Hematology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
⁷ Service de Médecine Vasculaire et Thérapeutique, CHU de St-Etienne, St-Etienne, France.
⁸ INSERM, UMR1059, Equipe Dysfonction Vasculaire et Hémostase, Université Jean-Monnet, St-Etienne, France.
⁹ FCRIN-INNOVTE, St-Etienne, France.
¹⁰ Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
¹¹ Department of Medicine, Division of Hematology-Oncology, New York Presbyterian Hospital of Weill Cornell Medical College, New York, NY, USA.

No abstract available

References

1. Say L, Chou D, Gemmill A, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2:e323-e333.
1. Sinha P, Kuruba N. Ante-partum haemorrhage: an update. J Obstet Gynaecol. 2008;28:377-381.
1. Dahlke JD, Mendez-Figueroa H, Maggio L, et al. Prevention and management of postpartum hemorrhage: a comparison of 4 national guidelines. Am J Obstet Gynecol. 2015;213:76.e1-76.e10.
1. Hackney DN, Glantz JC. Vaginal bleeding in early pregnancy and preterm birth: systemic review and analysis of heterogeneity. J Matern Fetal Neonatal Med. 2011;24:778-786.
1. Walfish M, Neuman A, Wlody D. Maternal haemorrhage. Br J Anaesth. 2009;103:i47-i56.