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. 2021 May;35(9):1399-1405.
doi: 10.1080/14786419.2019.1650357. Epub 2019 Aug 12.

Sesquiterpenoids from Saussurea costus

Tran Thi Hong Hanh  1 , Pham Thi Cham  1 , Nguyen Thi Thuy My  2 , Nguyen The Cuong  3 , Nguyen Hai Dang  1 , Tran Hong Quang  1 , Tran Thu Huong  2 , Nguyen Xuan Cuong  1 , Nguyen Hoai Nam  1 , Chau Van Minh  1
Affiliations

Sesquiterpenoids from Saussurea costus

Tran Thi Hong Hanh et al. Nat Prod Res. 2021 May.

Abstract

Sixteen sesquiterpenoids (1 - 16), including two new compounds namely saussucostusosides A and B (1 and 2), were isolated from the roots of Saussurea costus by various chromatographic separations. Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among isolated compounds, costunlide (6), 3β-[4-hydroxymethacryloyloxy]-8α-hydroxycostunolide (10) and 11β,13-dihydrozaluzanin C (16) exhibited potent inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 7.08 ± 0.34, 2.40 ± 0.06 and 5.55 ± 0.24 µM, respectively.

Keywords: Asteraceae; NO production; Saussurea costus; sesquiterpenoid.

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