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Review
. 2019 Jun 8:3:100060.
doi: 10.1016/j.eurox.2019.100060. eCollection 2019 Jul.

Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

Nida Ajmal  1 , Sanam Zeib Khan  1 , Rozeena Shaikh  1
Affiliations
Review

Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

Nida Ajmal et al. Eur J Obstet Gynecol Reprod Biol X. .

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous condition which is related to an endocrine reproductive disorder of females. It affects females of 18-44 age. The persistent hormonal disbalance leads to the complexities such as numerous cysts, an irregular menstrual cycle that ultimately leads to infertility among females. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. This review has highlighted different genes and their correlation with PCOS that leads to hormonal disbalance. Yet not in-depth but an attempt to study the genetic predisposition of PCOS.

Keywords: Endocrine reproductive disorder; Hormonal disbalance; Infertility; Polycystic ovary syndrome.

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Figures

Fig. 1
Fig. 1
PCOS long term condition.
Fig. 2
Fig. 2
how insulin resistance effects the ovarian theca cells and perturbs its functioning [18].
Fig. 3
Fig. 3
A defect in the pituitary axis elates testosterone and LH. It also leads to insulin resistance. Together insulin resistance and high level of androgen subsidize in the pathway of anovulation [19].
Fig. 4
Fig. 4
effect of steroidogenesis enzyme and theca cells of an ovary.
Fig. 5
Fig. 5
Flowchart that illustrate how insulin resistance leads to elevated level of androgen. It also explains decrease level of androgen that can be possible by using drugs that prevents insulin resistance (55).
See this image and copyright information in PMC

References

    1. Torie Comeaux Plowden M.D. Eunice Kennedy Shriver National Institute of Child Health and Human Development; 2016. M.P.H. Reproductive endocrinology and infertility.
    1. Legro R.S. 2009. Stein-Leventhal syndrome. Encyclopedia britannica.
    1. Teede H.D.A., Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8(1) - PMC - PubMed
    1. Ricardo Azziz M.D. M.P.H. Introduction: determinants of polycystic ovary syndrome. Fertil Steril. 2016;106(July (1)) - PubMed
    1. ranjith reddy K. POLYCYSTIC Ovary Syndrome: ROLE OF AROMATASE GENE VARIANTS IN SOUTH INDIAN WOMEN. Int J Pharma Bio Sci. 2015;6(2)

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