Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 9;8(8):297.
doi: 10.3390/antiox8080297.

Antioxidants: Terminology, Methods, and Future Considerations

Khiena Brainina  1   2 , Natalia Stozhko  3 , Marina Vidrevich  3
Affiliations

Antioxidants: Terminology, Methods, and Future Considerations

Khiena Brainina et al. Antioxidants (Basel). .

Abstract

Unreliable terminology and incompatible units of antioxidant activity/concentration expression lead to the failure of antioxidant clinical trials, ambiguity of conclusions about the effect of a chosen therapy in medicine and evaluation of food quality, diet, difficulties using information in monitoring the training process in sports, etc. Many different terms (antiradical activity, antioxidant activity, antioxidant capacity, antioxidant power, antioxidant ability) and methods: Trolox equivalent capacity assay (TEAC), Ferric Reducing Antioxidant Power assay (FRAP), Cupric Reducing Antioxidant Capacity assay (CUPRAC), antioxidative activity assay (ABTS), the oxygen radical absorbance capacity (ORAC), and different options of electrochemical ones) proposed for the determination of antioxidants are described. Possible approaches to the development of this field of science and practice are considered.

Keywords: antioxidants; methods; terminology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Use of terms in 2000–2018.
Figure 2
Figure 2
Frequency of terms used in 2000–2018.
See this image and copyright information in PMC

References

    1. 18th ISANH Middle East Antioxidants World Congress, Beirut Antioxidants 2017. [(accessed on 21 June 2019)]; Available online: https://www. isanh-me.com.
    1. Montezano A.C., Dulak-Lis M., Tsiropoulou S., Harvey A., Brione A.M., Touyz R.M. Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies. Can. J. Cardiol. 2015;31:631–641. doi: 10.1016/j.cjca.2015.02.008. - DOI - PubMed
    1. Siti H.N., Kamisaha Y., Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease. Vasc. Pharmacol. 2015;71:40–56. doi: 10.1016/j.vph.2015.03.005. - DOI - PubMed
    1. Brainina K.Z., Gerasimova E.L., Kazakov J.E., Khodos M. Oxidative stress: Nature, contribution to pathogenesis, protection and diagnosis. In: Budnikov G.K., editor. Problems of Analytical Chemistry. Nauka; Moscow, Russian: 2010. pp. 132–163.
    1. Cortina-Puig M., Prieto-Simón B., Campàs M., Calas-Blanchard C., Marty J.-L. Determination of the antioxidants’ ability to scavenge free radicals using biosensors. Adv. Exp. Med. Biol. 2010;698:222–233. - PubMed

LinkOut - more resources