Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug 10;17(8):467.
doi: 10.3390/md17080467.

Marine Collagen as A Promising Biomaterial for Biomedical Applications

Ye-Seon Lim  1 , Ye-Jin Ok  1 , Seon-Yeong Hwang  1 , Jong-Young Kwak  2 , Sik Yoon  3
Affiliations
Review

Marine Collagen as A Promising Biomaterial for Biomedical Applications

Ye-Seon Lim et al. Mar Drugs. .

Abstract

This review focuses on the expanding role of marine collagen (MC)-based scaffolds for biomedical applications. A scaffold-a three-dimensional (3D) structure fabricated from biomaterials-is a key supporting element for cell attachment, growth, and maintenance in 3D cell culture and tissue engineering. The mechanical and biological properties of the scaffolds influence cell morphology, behavior, and function. MC, collagen derived from marine organisms, offers advantages over mammalian collagen due to its biocompatibility, biodegradability, easy extractability, water solubility, safety, low immunogenicity, and low production costs. In recent years, the use of MC as an increasingly valuable scaffold biomaterial has drawn considerable attention from biomedical researchers. The characteristics, isolation, physical, and biochemical properties of MC are discussed as an understanding of MC in optimizing the subsequent modification and the chemistries behind important tissue engineering applications. The latest technologies behind scaffold processing are assessed and the biomedical applications of MC and MC-based scaffolds, including tissue engineering and regeneration, wound dressing, drug delivery, and therapeutic approach for diseases, especially those associated with metabolic disturbances such as obesity and diabetes, are discussed. Despite all the challenges, MC holds great promise as a biomaterial for developing medical products and therapeutics.

Keywords: 3D cell culture; marine collagen; scaffolds; tissue engineering; tissue regeneration.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various beneficial characteristics of marine collagen.
Figure 2
Figure 2
Biomaterials, key factors, and types of scaffolds for tissue engineering.
Figure 3
Figure 3
A schematic diagram of marine collagen isolation from marine sources.
Figure 4
Figure 4
Marine collagen as a biomaterial for biomedical applications.
See this image and copyright information in PMC

References

    1. Brinckmann J. Collagens at a Glance. Top. Curr. Chem. 2005;247:1–6. doi: 10.1007/b103817. - DOI
    1. Kular J.K., Basu S., Sharma R.I. The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering. J. Tissue Eng. 2014;5:1–17. doi: 10.1177/2041731414557112. - DOI - PMC - PubMed
    1. Song F., Wisithphrom K., Zhou J., Windsor L.J. Matrix metalloproteinase dependent and independent collagen degradation. Front. Biosci. 2006;11:3100–3120. doi: 10.2741/2036. - DOI - PubMed
    1. Parenteau-Bareil R., Gauvin R., Cliché S., Gariépy C., Germain L., Berthod F. Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis. Acta Biomater. 2011;7:3757–3765. doi: 10.1016/j.actbio.2011.06.020. - DOI - PubMed
    1. Gorgieva S., Kokol V. Biomaterials Applications for Nanomedicine. InTech; London, UK: 2011. pp. 17–52. Chapter 2.

LinkOut - more resources