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Review
. 2019 Aug 11;11(8):403.
doi: 10.3390/pharmaceutics11080403.

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

Daniele Massella  1   2   3 , Monica Argenziano  4 , Ada Ferri  5 , Jinping Guan  6 , Stéphane Giraud  7 , Roberta Cavalli  4 , Antonello A Barresi  5 , Fabien Salaün  7
Affiliations
Review

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

Daniele Massella et al. Pharmaceutics. .

Abstract

In the field of pharmaceutical technology, significant attention has been paid on exploiting skin as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation. In this context, a new class of materials called bio-functional textiles has been developed. Such materials consist of the combination of advanced pharmaceutical carriers with textile materials. Therefore, they own the possibility of providing a wearable platform for continuous and controlled drug release. Notwithstanding the great potential of these materials, their large-scale application still faces some challenges. The present review provides a state-of-the-art perspective on the bio-functional textile technology analyzing the several issues involved. Firstly, the skin physiology, together with the dermatological delivery strategy, is keenly described in order to provide an overview of the problems tackled by bio-functional textiles technology. Secondly, an overview of the main dermatological nanocarriers is provided; thereafter the application of these nanomaterial to textiles is presented. Finally, the bio-functional textile technology is framed in the context of the different dermatological administration strategies; a comparative analysis that also considers how pharmaceutical regulation is conducted.

Keywords: biomedical materials; electrospinning; encapsulation; fibers; nanocarriers; regulatory issues; skin; textiles; transdermal drug delivery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme of skin layers. The references in the image point out: (1) hair shaft; (2) stratum corneum; (3) sweat-pore; (4) hair follicle; (5) arrector pili muscle; (6) sebaceous gland; (7) nerve; (8) eccrine sweat gland; (9) cutaneous vascular plexes; (10) adipose depot. Section (A) and (B) highlight a detailed structure of the epidermis and derma respectively. [Reproduced from Gaur et al. [67] which is licensed under a Creative Commons Attribution-(CC BY 4.0) International License (http://creativecommons.org/licenses/by/4.0/)].
Figure 2
Figure 2
Transdermal transport and penetration pathway (reproduced from Bolzinger et al. (2012) [87], with permission from Elsevier).
Figure 3
Figure 3
Finishing techniques for bio-functional textile production.
See this image and copyright information in PMC

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