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Case Reports
. 2019 Sep 23;63(10):e02474-18.
doi: 10.1128/AAC.02474-18. Print 2019 Oct.

Isavuconazole Diffusion in Infected Human Brain

Claire Rouzaud  1 , Vincent Jullien  2 , Anne Herbrecht  3 , Bruno Palmier  4 , Simona Lapusan  5 , Marjolaine Morgand  1 , Romain Guéry  1 , Amélie Dureault  1 , François Danion  1 , Stéphanie Puget  6 , Lauriane Goldwirt  2 , Fanny Lanternier  1   7 , Olivier Lortholary  8   7
Affiliations
Case Reports

Isavuconazole Diffusion in Infected Human Brain

Claire Rouzaud et al. Antimicrob Agents Chemother. .

Abstract

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.

Keywords: cerebral aspergillosis; isavuconazole; pharmacokinetic; therapeutic drug monitoring.

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Figures

FIG 1
FIG 1
(A) T1-gadolinium cerebral magnetic resonance imaging showing a frontal abscess due to Aspergillus fumigatus infection before the second surgical procedure and (B) the resection specimen.
See this image and copyright information in PMC

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