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. 2019 Oct 22;63(11):e00646-19.
doi: 10.1128/AAC.00646-19. Print 2019 Nov.

Spread of NDM-5 and OXA-181 Carbapenemase-Producing Escherichia coli in Chad

Oumar Ouchar Mahamat  1   2   3 , Manon Lounnas  4   2 , Mallorie Hide  2 , Abelsalam Tidjani  5 , Julio Benavides  6 , Abibatou Diack  2 , Calèbe Somasse  4   2 , Kadidja Gamougam  7 , Christian Carrière  4   2 , Dominique Decré  8   9 , Anne-Laure Bañuls  2   10 , Hélène Jean-Pierre  4   2 , Yann Dumont #  4   2 , Fabrice Compain #  11   12 , Sylvain Godreuil #  4   2   10
Affiliations

Spread of NDM-5 and OXA-181 Carbapenemase-Producing Escherichia coli in Chad

Oumar Ouchar Mahamat et al. Antimicrob Agents Chemother. .

Abstract

We detected for the first time blaNDM-5 and blaOXA-181 in Escherichia coli isolates from hospitalized patients and healthy volunteers in Chad. These resistance genes were located on IncX3 and IncF plasmids. Despite the large diversity of E. coli clones, the identified resistant intestinal isolates belonged mainly to the same sequence type.

Keywords: Chad; Escherichia coli; carbapenemases; clinical samples; fecal carriage prevalence.

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Figures

FIG 1
FIG 1
UPGMA dendrogram based on the variable-number tandem-repeat (VNTR) (9 loci) and MLST data for the 18 CPEc isolates. The relationships between patterns were assessed using the UPGMA hierarchical clustering method. ST, sequence type; NTP, nontypeable plasmid; HGRN, National Reference General Hospital; RH, Renaissance Hospital; MCH, Mother and Child Hospital; ICU, Intensive Care Unit.
See this image and copyright information in PMC

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