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Comment
. 2019 Sep 2;216(9):1972-1973.
doi: 10.1084/jem.20191098. Epub 2019 Aug 12.

ILC2s chew the fat

Roberto R Ricardo-Gonzalez  1 , Richard M Locksley  2   3   4
Affiliations
Comment

ILC2s chew the fat

Roberto R Ricardo-Gonzalez et al. J Exp Med. .

Abstract

In this issue of JEM, Rana et al. (https://doi.org/10.1084/jem.20190689) report that adipose tissue multipotent stromal cells (MSCs) provide multifaceted support for adipose tissue-resident ILC2s through contact-mediated proliferation and IL-33-mediated stress-induced activation.

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Figures

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Insights from Roberto R. Ricardo-Gonzalez and Richard M. Locksley.
See this image and copyright information in PMC

Comment on

  • A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.
    Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. Rana BMJ, et al. J Exp Med. 2019 Sep 2;216(9):1999-2009. doi: 10.1084/jem.20190689. Epub 2019 Jun 27. J Exp Med. 2019. PMID: 31248899 Free PMC article.

References

    1. Dahlgren M.W., et al. . 2019. Immunity. 10.1016/j.immuni.2019.02.002 - DOI - PubMed
    1. Ganeshan K., et al. . 2019. Cell. 10.1016/j.cell.2019.01.050 - DOI - PubMed
    1. Gasteiger G., and Rudensky A.Y. Nat. Rev. Immunol. 2014 doi: 10.1038/nri3726. - DOI - PMC - PubMed
    1. Huang Y., et al. . 2018. Science. 10.1126/science.aam5809 - DOI
    1. Koga S., et al. J. Exp. Med. 2018 doi: 10.1084/jem.20172310. - DOI - PubMed