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Review
. 2019 Jul 29;4(Suppl 6):e001289.
doi: 10.1136/bmjgh-2018-001289. eCollection 2019.

Clinical emergency care research in low-income and middle-income countries: opportunities and challenges

Adam R Aluisio  1 , Shahan Waheed  2 , Peter Cameron  3 , Jermey Hess  4 , Shevin T Jacob  5 , Niranjan Kissoon  6 , Adam C Levine  1 , Asad Mian  2 , Shammi Ramlakhan  7   8 , Hendry R Sawe  9 , Junaid Razzak  10
Affiliations
Review

Clinical emergency care research in low-income and middle-income countries: opportunities and challenges

Adam R Aluisio et al. BMJ Glob Health. .

Erratum in

Abstract

Disease processes that frequently require emergency care constitute approximately 50% of the total disease burden in low-income and middle-income countries (LMICs). Many LMICs continue to deal with emergencies caused by communicable disease states such as pneumonia, diarrhoea, malaria and meningitis, while also experiencing a marked increase in non-communicable diseases, such as cardiovascular diseases, diabetes mellitus and trauma. For many of these states, emergency care interventions have been developed through research in high-income countries (HICs) and advances in care have been achieved. However, in LMICs, clinical research, especially interventional trials, in emergency care are rare. Furthermore, there exists minimal research on the emergency management of diseases, which are rarely encountered in HICs but impact the majority of LMIC populations. This paper explores challenges in conducting clinical research in patients with emergency conditions in LMICs, identifies examples of successful clinical research and highlights the system, individual and study design characteristics that made such research possible in LMICs. Derived from the available literature, a focused list of high impact research considerations are put forth.

Keywords: diseases; disorders; injuries; public health; study design.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Publications in emergency care clinical research by income strata over time.
See this image and copyright information in PMC

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