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Randomized Controlled Trial
. 2019 Nov;47(11):5483-5496.
doi: 10.1177/0300060519859766. Epub 2019 Aug 13.

Effect of Pushen capsule for treating vascular mild cognitive impairment: a pilot observational study

Shuo Li  1 , Geyin Cao  1 , Qiwen Deng  2 , Dan Zhu  1 , Fuling Yan  1
Affiliations
Randomized Controlled Trial

Effect of Pushen capsule for treating vascular mild cognitive impairment: a pilot observational study

Shuo Li et al. J Int Med Res. 2019 Nov.

Abstract

Objective: Traditional Chinese medicine (TCM) may be beneficial for vascular dementia (VaD). We evaluated the efficacy of Pushen capsule, a compound containing several TCM components, for treating vascular mild cognitive impairment (VaMCI).

Methods: Seventy outpatients with VaMCI were randomized to Pushen capsule or control treatment with Ginkgo biloba. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Subjective Memory Loss Rating Scale scores; and lipid, lipoprotein, and haemorheological parameters were collected at baseline, week 4, and week 12 of treatment.

Results: MMSE score at week 12 was significantly higher in the treatment group compared with baseline (t = −2.352) but was not significantly different from week 12 in the control group. The MoCA score at week 12 was higher than that at baseline for both the treatment and control groups (t = −2.619 and −2.582, respectively), as was the “delayed recall” item score. Subjective memory loss score and the cognitive function “forgetting acquaintance's name” were significantly higher in the treatment group at week 12 than at baseline (t = −2.621 and χ2 = 4.419, respectively). Lipid, lipoprotein, and haemorheological parameters were significantly different after treatment in both groups.

Conclusion: The benefits of Pushen capsule on cognitive function in VaMCI were comparable with that of Ginkgo biloba.

Keywords: Ginkgo biloba; Mini Mental State Examination; Pushen capsule; Vascular mild cognitive impairment; cognitive function; randomized controlled trial.

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Figures

Figure 1.
Figure 1.
Effect of Pushen capsule and Ginkgo biloba tablets on cognitive function as assessed by MMSE (a), MoCA (b), and Subjective Memory Loss Rating Scale (c).
See this image and copyright information in PMC

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