It's complicated!
- PMID: 31408588
- DOI: 10.1111/ajt.15563
It's complicated!
Keywords: animal models: murine; editorial/personal viewpoint; immunosuppression/immune modulation; microbiomics.
Comment on
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Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4+ Foxp3+ regulatory T cell levels.Am J Transplant. 2019 Oct;19(10):2705-2718. doi: 10.1111/ajt.15523. Epub 2019 Aug 2. Am J Transplant. 2019. PMID: 31278849 Free PMC article.
References
REFERENCES
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- Guo Y, Wang Q, Li D, et al. Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4+Foxp3+ regulatory T cell levels [published online ahead of print August 2, 2019]. Am J Transplant. https://doi.org/10.1111/ajt.15523.
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- Bromberg JS, Hittle L, Xiong Y, et al. Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. JCI Insight. 2018;3(19), 121045. https://doi.org/10.1172/jci.insight.121045.
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- Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331(6015):337-341. https://doi.org/10.1126/science.1198469.
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- Lei YM, Chen L, Wang Y, et al. The composition of the microbiota modulates allograft rejection. J Clin Invest. 2016;126(7):2736-2744. https://doi.org/10.1172/jci85295.
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- Chung BH, Oh HJ, Piao SG, et al. Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection. Immunology. 2012;136(3):344-351. https://doi.org/10.1111/j.1365-2567.2012.03588.x.
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