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Comment
. 2019 Aug 12;36(2):115-117.
doi: 10.1016/j.ccell.2019.07.004.

Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome

Yehudit Birger  1 , Ruth Shiloh  1 , Shai Izraeli  2
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Comment

Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome

Yehudit Birger et al. Cancer Cell. .
Free article

Abstract

Studies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.

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  • Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
    Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH. Labuhn M, et al. Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11. Cancer Cell. 2019. PMID: 31303423 Free PMC article.

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