Oligodendrocyte K_ir4.1 Channels Clear Out Congested K

Comment

Kyle A Lyman et al. Epilepsy Curr. 2019 Sep.

. 2019 Sep;19(5):339-340.

doi: 10.1177/1535759719868185. Epub 2019 Aug 13.

Abstract

[Box: see text].

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility.
Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Larson VA, et al. Elife. 2018 Mar 29;7:e34829. doi: 10.7554/eLife.34829. Elife. 2018. PMID: 29596047 Free PMC article.

1. Fröhlich F, Bazhenov M, Iragui-Madoz V, Sejnowski TJ. Potassium dynamics in the epileptic cortex: new insights on an old topic. Neuroscientist. 2008;14(5):422–433. - PMC - PubMed
1. Wetherington J, Serrano G, Dingledine R. Astrocytes in the Epileptic Brain. Neuron. 2008;58(2):168–178. - PMC - PubMed
1. Green JD. The Hippocampus. Physiol Rev. 1964;44:561–608. - PubMed
1. Schirmer L, Möbius W, Zhao C. et al. Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. Elife. 2018;7:pii: e36428. - PMC - PubMed
1. Menichella DM, Majdan M, Awatramani R. et al. Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity. J Neurosci. 2006;26(43):10984–10991. - PMC - PubMed