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. 2019 Sep;19(5):316-320.
doi: 10.1177/1535759719868186. Epub 2019 Aug 13.

Adult Neurogenesis in the Development of Epilepsy

Steve C Danzer  1   2   3   4
Affiliations

Adult Neurogenesis in the Development of Epilepsy

Steve C Danzer. Epilepsy Curr. 2019 Sep.

Abstract

Compelling evidence indicates that hippocampal dentate granule cells are generated throughout human life and into old age. While animal studies demonstrate that these new neurons are important for memory function, animal research also implicates these cells in the pathogenesis of temporal lobe epilepsy. Several recent preclinical studies in rodents now suggest that targeting these new neurons can have disease-modifying effects in epilepsy.

Keywords: basal dendrite; cell ablation; dentate granule cell; dentate gyrus; ectopic cells; epilepsy therapy; epileptogenesis; hippocampus; mossy fiber sprouting.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declares no potential conflict of interest with respect to the research, authorship, and/or publication of this article.

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