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. 2019 Aug 13;6(1):148.
doi: 10.1038/s41597-019-0154-y.

DRAMP 2.0, an updated data repository of antimicrobial peptides

Xinyue Kang  1 , Fanyi Dong  1 , Cheng Shi  1 , Shicai Liu  2 , Jian Sun  3 , Jiaxin Chen  1 , Haiqi Li  1 , Hanmei Xu  4 , Xingzhen Lao  5 , Heng Zheng  6
Affiliations

DRAMP 2.0, an updated data repository of antimicrobial peptides

Xinyue Kang et al. Sci Data. .

Abstract

Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/ ) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The number of overlapping and non-overlapping sequences of DRAMP, APD and CAMP. The number of non-overlapping sequences is calculated as a percentage in the corresponding database (data as of 2019.1.1).
Fig. 2
Fig. 2
Visualization of detailed information page of DRAMP 2.0. In the red box is the update content. The screenshot in the figure is from DRAMP18533.
Fig. 3
Fig. 3
Visualization of detailed information page of DRAMP 2.0. In the red box is the update content. The screenshot in the figure is from DRAMP00090.
Fig. 4
Fig. 4
The new classifications by taxonomy and activity of DRAMP 2.0 in browse page (http://dramp.cpu-bioinfor.org/browse/). In the red box is the update content.
Fig. 5
Fig. 5
The relationship map of classifications by activity in DRAMP 2.0. In the red box is the main classifications of DRAMP.
Fig. 6
Fig. 6
The new download page has been dedicatedly designed in DRAMP 2.0 (http://dramp.cpu-bioinfor.org/downloads/). The top-down four tables contain the links of datasets, activities, software, and website source code.
See this image and copyright information in PMC

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