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Review
. 2019 Jul 17:12:2151-2160.
doi: 10.2147/IDR.S193649. eCollection 2019.

Staphyloxanthin: a potential target for antivirulence therapy

Lijun Xue  1   2 , Yang Yizhi Chen  1 , Zhiyun Yan  3 , Wei Lu  1 , Dong Wan  4 , Huifeng Zhu  1
Affiliations
Review

Staphyloxanthin: a potential target for antivirulence therapy

Lijun Xue et al. Infect Drug Resist. .

Abstract

Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of S. aureus infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy.

Keywords: antiinfective drug; antivirulence therapy; staphyloxanthin; target.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The pathways of staphyloxanthin biosynthesis. The pigments were dissolved in ethyl acetate and the absorption spectra was measured.
Figure 2
Figure 2
The organization of the crt genes in 58 published S. aureus genomes. The color of the arrows represents the color of the product encoded by corresponding gene.
See this image and copyright information in PMC

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