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Comparative Study
. 1988 Aug;7(4):549-51.
doi: 10.1007/BF01962613.

In vitro activity and beta-lactamase stability of LY163892

E Pelosi  1 , R Fontana
Affiliations
Comparative Study

In vitro activity and beta-lactamase stability of LY163892

E Pelosi et al. Eur J Clin Microbiol Infect Dis. 1988 Aug.

Abstract

Susceptibility testing of clinical isolates of several gram-negative and gram-positive species showed LY163892 to be more active than cefaclor and cephalexin. OXA-2, TEM-1, TEM-2, PSE-1, CEP-1, CARB-3 and SHV-1 beta-lactamases showed similar activity against LY163892 and cefaclor, whereas OXA-1 hydrolyzed the latter more rapidly. Organisms producing these beta-lactamases, but not TEM-2 and CEP-1, appeared to be more susceptible to LY163892 than cephalexin, although cephalexin proved to be more resistant to beta-lactamase activity. Strains producing TEM-2 and CEP-1 were resistant to LY163892, cefaclor and cephalexin.

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References

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