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. 1988 Aug;79(8):917-20.
doi: 10.1111/j.1349-7006.1988.tb00055.x.

Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde

C Furihata  1 , A Yamakoshi, T Matsushima
Affiliations

Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde

C Furihata et al. Jpn J Cancer Res. 1988 Aug.

Abstract

Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor-promoting activity in carcinogenesis in the glandular stomach.

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References

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