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Case Reports
. 2020 Apr 15;70(9):1998-2001.
doi: 10.1093/cid/ciz782.

Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation

Mario Corbellino  1 , Nicolas Kieffer  2 , Mzia Kutateladze  3 , Nana Balarjishvili  3 , Lika Leshkasheli  3 , Lia Askilashvili  3 , George Tsertsvadze  3 , Sara Giordana Rimoldi  4 , Deia Nizharadze  5 , Naomi Hoyle  5 , Lia Nadareishvili  5 , Spinello Antinori  1   6 , Cristina Pagani  4 , Daniele Giuseppe Scorza  4 , Ai Ling Loredana Romanò  7 , Sandro Ardizzone  6   8 , Piergiorgio Danelli  6   9 , Maria Rita Gismondo  4   6 , Massimo Galli  1   6 , Patrice Nordmann  2 , Laurent Poirel  2
Affiliations
Case Reports

Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation

Mario Corbellino et al. Clin Infect Dis. .

Abstract

In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.

Keywords: antibiotic resistance; bacteriophage; multidrug-resistant Klebsiella pneumoniae; personalized phage therapy; selective decolonization.

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