Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov;144(5):1450-1453.
doi: 10.1016/j.jaci.2019.07.036. Epub 2019 Aug 13.

A comprehensive characterization of chronic norovirus infection in immunodeficient hosts

Li-An K Brown  1 , Christopher Ruis  2 , Ian Clark  3 , Sunando Roy  4 , Julianne R Brown  5 , Adriana S Albuquerque  6 , Smita Y Patel  7 , Joanne Miller  8 , Mohammed Yousuf Karim  9 , Samir Dervisevic  10 , Jennifer Moore  10 , Charlotte A Williams  4 , Juliana Cudini  4 , Fernando Moreira  11 , Penny Neild  12 , Suranjith L Seneviratne  11 , Sarita Workman  11 , Christos Toumpanakis  13 , Claire Atkinson  6 , Siobhan O Burns  14 , Judith Breuer  4 , David M Lowe  15
Affiliations

A comprehensive characterization of chronic norovirus infection in immunodeficient hosts

Li-An K Brown et al. J Allergy Clin Immunol. 2019 Nov.
No abstract available

PubMed Disclaimer

Figures

Fig 1
Fig 1
Long-term average (from 2000 [or date of CVID diagnosis, if later] to 2018) CD3+ and CD19+ values for 8 patients with CVID with CNI versus 113 patients with CVID without CNI. Lines represent medians. P values are from Mann-Whitney tests.
Fig 2
Fig 2
Effect of interventions on symptoms and norovirus clearance. Effect on symptoms: green, improvement; orange, no clear effect; red, deterioration; and white, not attempted. Effect on norovirus clearance: green, sustained decrease in viral load or multiple negative samples; orange, no clear effect; red, relapse or increase in viral load; and white, not attempted. *Symptomatically improved with Pentaglobin but no viral clearance. **Apparent initial response but subsequent relapse during treatment. Further episode of infection 2 years later resolved rapidly with ribavirin therapy. ***Evidence of likely treatment-related anemia.
Fig E1
Fig E1
Fig E3
Fig E3
Fig E4
Fig E4
Fig E5
Fig E5
Fig E7
Fig E7
Fig E8
Fig E8
See this image and copyright information in PMC

References

    1. Brown L.K., Clark I., Brown J.R., Breuer J., Lowe D.M. Norovirus infection in primary immune deficiency. Rev Med Virol. 2017;23:e1926. - PubMed
    1. Brown J.R., Roy S., Ruis C., Yara Romero E., Shah D., Williams R. Norovirus whole-genome sequencing by SureSelect target enrichment: a robust and sensitive method. J Clin Microbiol. 2016;54:2530–2537. - PMC - PubMed
    1. Brown J.R., Roy S., Tutill H., Williams R., Breuer J. Super-infections and relapses occur in chronic norovirus infections. J Clin Virol. 2017;96:44–48. - PubMed
    1. Nei M., Li W.H. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc Natl Acad Sci U S A. 1979;76:5269–5273. - PMC - PubMed
    1. Depledge D.P., Cudini J., Kundu S., Atkinson C., Brown J.R., Haque T. High viral diversity and mixed infections in cerebral spinal fluid from cases of varicella zoster virus encephalitis. J Infect Dis. 2018;218:1592–1601. - PMC - PubMed

Publication types

MeSH terms