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Review
. 2019 Jun 17:14:4449-4460.
doi: 10.2147/IJN.S208332. eCollection 2019.

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

Hanie Yavarpour-Bali  1 , Maryam Ghasemi-Kasman  2   3 , Marzieh Pirzadeh  1
Affiliations
Review

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

Hanie Yavarpour-Bali et al. Int J Nanomedicine. .

Abstract

Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.

Keywords: bioavailability; central nervous system diseases; curcumin; nanoparticles; water solubility.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Nano-based drug delivery system for targeted delivery and enhancement of water solubility and bioavailability of curcumin. Abbreviation: CNS, Central nervous system.
See this image and copyright information in PMC

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