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Review
. 2019 Jun 18:12:4721-4728.
doi: 10.2147/OTT.S194153. eCollection 2019.

Oral microbiota and gastrointestinal cancer

Yangyang Zhang  1   2 , Qiaoli Niu  2 , Wenguo Fan  1 , Fang Huang  1 , Hongwen He  1
Affiliations
Review

Oral microbiota and gastrointestinal cancer

Yangyang Zhang et al. Onco Targets Ther. .

Abstract

The microbiota inhabiting the oral cavity is a complex ecosystem and responsible for resisting pathogens, maintaining homeostasis, and modulating the immune system. Some components of the oral microbiota contribute to the etiology of some oral diseases. Accumulating evidence suggests that the human oral microbiota is implicated in the development and progression of gastrointestinal cancer. In this review, we described the current understanding of possible roles and mechanisms of oral microbiota in the gastrointestinal cancers studied to date. The perspectives for oral microbiota as the biomarkers for early detection and new therapeutic targets were also discussed.

Keywords: etiology; gastrointestinal cancer; oral microbiota.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Possible Oral microbiota mechanisms in gastrointestinal cancer.Abbreviation: CRC, colorectal cancer.
See this image and copyright information in PMC

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