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. 1988 Oct;8(10):4552-6.
doi: 10.1128/mcb.8.10.4552-4556.1988.

The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2

A Eisen  1 , W E Taylor, H Blumberg, E T Young
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The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2

A Eisen et al. Mol Cell Biol. 1988 Oct.

Abstract

The yeast ADR1 protein contains two zinc finger domains that are essential for its role in transcriptional activation of alcohol dehydrogenase (ADH2). These domains are thought to function as DNA-binding structures. An ADR1-beta-galactosidase fusion protein made in Escherichia coli and containing the finger domains of ADR1 binds in vitro in a zinc-dependent manner to DNA fragments containing the two ADH2 upstream activation sequences. The strongest binding is to upstream activation sequence 1, a 22-base-pair palindrome.

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References

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