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. 2019 Aug 2:11:550-559.
doi: 10.1016/j.dadm.2019.05.003. eCollection 2019 Dec.

A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability

Rosie E Curiel Cid  1 , David A Loewenstein  1 , Monica Rosselli  2 , Jordi A Matias-Guiu  3 , Daema Piña  1 , Malek Adjouadi  4 , Mercedes Cabrerizo  4 , Russell M Bauer  5 , Aldrich Chan  1 , Steven T DeKosky  5 , Todd Golde  5 , Maria T Greig-Custo  6 , Gabriel Lizarraga  4 , Ailyn Peñate  6 , Ranjan Duara  6
Affiliations

A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability

Rosie E Curiel Cid et al. Alzheimers Dement (Amst). .

Abstract

Introduction: Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer's disease are needed.

Methods: Performance of Hispanic and non-Hispanic older adults on the Loewenstein-Acevedo Scale of Semantic Interference and Learning (LASSI-L) was examined in persons with amnestic mild cognitive impairment (aMCI) or normal cognition. The association between a novel cognitive marker, the failure to recover from proactive semantic interference (frPSI), and cortical thinning was explored.

Results: English-speaking aMCI participants scored lower than cognitively normal participants on all LASSI-L indices, while Spanish-speaking aMCI participants scored lower in learning, frPSI, and delayed recall. Healthy controls obtained equivalent scores on all indices except retroactive semantic interference. English-speaking and Spanish-speaking aMCI participants had equivalent scores except English speaker's greater vulnerability to frPSI. Across aMCI groups, frPSI was associated with cortical thinning of the entorhinal cortex and precuneus (r = -0.45 to r = 0.52; P < .005).

Discussion: In diverse populations, LASSI-L performance differentiated patients with aMCI from cognitively normal older adults and was associated with thinning in Alzheimer's disease-prone regions, suggesting its clinical utility.

Keywords: Cognitive assessment; Diversity; Mild cognitive impairment; Prodromal Alzheimer's disease; Semantic interference.

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References

    1. West L.A., Cole S., Goodkind D., He W. US Census Bureau; 2014. 65+ in the United States: 2010; pp. 23–212.
    1. Brookmeyer R., Johnson E., Ziegler-Graham K., Arrighi H.M. Forecasting the global burden of Alzheimer's disease. J Alzheimer's Dement. 2007;3:186–191. - PubMed
    1. Hebert L.E., Scherr P.A., L Bienias J., Bennett D.A., Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60:1119–1122. - PubMed
    1. US Alzheimer's Association Alzheimer's disease facts and figures. J Alzheimer's Dement. 2010;6:158–194. - PubMed
    1. Manly J.J. Advantages and disadvantages of separate norms for African Americans. Clin Neuropsychologist. 2005;19:270–275. - PubMed