Effect of dapagliflozin on arterial stiffness in patients with type 2 diabetes mellitus

Abstract

Introduction: Oral antidiabetic inhibitors of the sodium-glucose cotransporter (SGLT2i) reduce cardiovascular morbidity and mortality in DM2. The increase in arterial stiffness can participate in this morbidity and mortality. The aim of this study was to analyse the effect of the administration of dapagliflozin on arterial stiffness.

Patients and methods: Prospective observational study that included 32 patients with DM2. Before starting dapagliflozin, and at 6 and 12 months, biochemical parameters in blood and urine were analysed. Before starting dapagliflozin and at 12 months the velocity of the carotid-femoral pulse (VPc-f) was determined by tonometry. Changes in the variables and their interrelation was analysed by repeated data ANOVA, Wilcoxon's test and multiple regression.

Results: A significant decrease in the VPc-f was observed. There was no association between decreased VPc-f and changes in blood glucose, uric acid, blood pressure or weight.

Conclusions: Dapagliflozin, in subjects with DM2, produces a medium to long-term decrease in arterial stiffness.

Keywords: Arterial stiffness; Dapagliflozin; Dapagliflozina; Diabetes mellitus; Rigidez arterial.