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Review
. 2019 Dec 18;58(1):11-17.
doi: 10.1515/cclm-2019-0643.

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Emanuela Galliera  1   2 , Luca Massaccesi  1 , Elena de Vecchi  2 , Giuseppe Banfi  2 , Massimiliano M Corsi Romanelli  1   3
Affiliations
Free article
Review

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Emanuela Galliera et al. Clin Chem Lab Med. .
Free article

Abstract

The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.

Keywords: bacterial infection; presepsin; serum marker.

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References

    1. Jacobs L, Wong HR. Emerging infection and sepsis biomarkers: will they change current therapies? Expert Rev Anti Infect Ther 2016;14:929–41.
    1. Alizadeh N, Memar MY, Moaddab SR, Kafil HS. Aptamer-assisted novel technologies for detecting bacterial pathogens. Biomed Pharmacother 2017;93:737–45.
    1. Marazzi MG, Randelli F, Brioschi M, Drago L, Romano CL, Banfi G, et al. Presepsin: a potential biomarker of PJI? A comparative analysis with known and new infection biomarkers. Int J Immunopathol Pharmacol 2018;31:1–10.
    1. Chenevier-Gobeaux C, Borderie D, Weiss N, Mallet-Coste T, Claessens YE. Presepsin [sCD14-ST], an innate immune response marker in sepsis. Clin Chim Acta 2015;450:97–103.
    1. Zou Q, Wen W, Zhang XC. Presepsin as a novel sepsis biomarker. World J Emerg Med 2014;5:16–9.