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Review
. 2019 Aug;5(8):457-459.
doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.

Targeting Metabolic Bottlenecks in Lung Cancer

Volkan I Sayin  1 , Sarah E LeBoeuf  2 , Thales Papagiannakopoulos  3
Affiliations
Review

Targeting Metabolic Bottlenecks in Lung Cancer

Volkan I Sayin et al. Trends Cancer. 2019 Aug.

Abstract

Lung cancer remains one of the most genetically complex, aggressive, and lethal solid malignancies. Understanding how distinct lung cancer mutations give rise to altered nutrient requirements and promote immune evasion in the context of a heterogeneous lung tumor microenvironment is vital for the development of novel personalized therapeutic strategies.

Keywords: KEAP1; STK11/LKB1; immune evasion; lung cancer; metabolism; microenvironment.

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