Multicenter Study

. 2020 Feb 26;46(2):432-441.

doi: 10.1093/schbul/sbz067.

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

Stefania Tognin^{1

2}, Hendrika H van Hell³, Kate Merritt¹, Inge Winter-van Rossum³, Matthijs G Bossong³, Matthew J Kempton¹, Gemma Modinos¹, Paolo Fusar-Poli^{1

4

5}, Andrea Mechelli¹, Paola Dazzan¹, Arija Maat³, Lieuwe de Haan⁶, Benedicto Crespo-Facorro^{7

8

9}, Birte Glenthøj^{10

11}, Stephen M Lawrie¹², Colm McDonald¹³, Oliver Gruber¹⁴, Therese van Amelsvoort¹⁵, Celso Arango¹⁶, Tilo Kircher¹⁷, Barnaby Nelson^{18

19}, Silvana Galderisi²⁰, Rodrigo Bressan²¹, Jun S Kwon²², Mark Weiser^{23

24}, Romina Mizrahi^{25

26

27}, Gabriele Sachs²⁸, Anke Maatz²⁹, René Kahn^{3

30}, Phillip McGuire^{1

2

5}; PSYSCAN Consortium

Collaborators, Affiliations

Collaborators

PSYSCAN Consortium:
Philip McGuire, Stefania Tognin, Paolo Fusar-Poli, Matthew Kempton, Gemma Modinos, Kate Merritt, Andrea Mechelli, Paola Dazzan, George Gifford, Natalia Petros, Mathilde Antoniades, Andrea De Micheli, Sandra Vieira, Tom J Spencer, Cristina Scarpazza, Emily Hird, Rene Kahn, Arija Maat, Erika van Hell, Inge Winter, Wiepke Cahn, Hugo Schnack, Lieuwe de Haan, Dieuwke Siegmann, Jana Barkhof, Lotte Hendriks, Iris de Wit, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Esther Setien-Suero, Rosa Ayesa-Arriola, Paula Suarez-Pinilla, MariaLuz Ramirez-Bonilla, Victor Ortiz Garcia-de la Foz, Birte Glenthøj, Mikkel Erlang Sørensen, Karen Tangmose, Helle Schæbel, Brian Broberg, Egill Rostrup, Stephen Lawrie, Colm McDonald, Brian Hallahan, Dara Cannon, James McLoughlin, Martha Finnegan, Oliver Gruber, Therese van Amelsvoort, Danny Deckers, Machteld Marcelis, Claudia Vingerhoets, Celso Arango, Covadonga M Díaz-Caneja, Miriam Ayora, Joost Janssen, Roberto Rodríguez-Jiménez, Marina Díaz-Marsá, Tilo Kircher, Irina Falkenberg, Florian Bitsch, Philipp Berger, Jens Sommer, Kyeon Raab, Babette Jakobi, Barnaby Nelson, Patrick McGorry, Paul Amminger, Meredith McHugh, Silvana Galderisi, Armida Mucci, Paola Bucci, Giuseppe Piegari, Daria Pietrafesa, Alessia Nicita, Sara Patriarca, Rodrigo Bressan, André Zugman, Ary Gadelha, Graccielle Rodrigues da Cunha, Jun Soo Kwon, Kang I K Kevin Cho, Tae Young Lee, Minah Kim, Yoo Bin Kwak, Wu Jeong Hwang, Mark Weiser, Romina Mizrahi, Michael Kiang, Cory Gerritsen, Margaret Maheandiran, Sarah Ahmed, Ivana Prce, Jenny Lepock, Gabriele Sachs, Matthäus Willeit, Marzena Lenczowski, Ullrich Sauerzopf, Ana Weidenauer, Julia Furtner-Srajer, Matthias Kirschner, Anke Maatz, Achim Burrer, Philipp Stämpfli, Naemi Huber, Stefan Kaiser, Wolfram Kawohl, Michael Brammer, Jonathan Young, Edward Bullmore, Sarah Morgan

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
² Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, London, UK.
³ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
⁴ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
⁵ National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
⁶ Department Early Psychosis, Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
⁷ CIBERSAM, Department of Psychiatry, University Hospital Virgen del Rocío, Sevilla, Spain.
⁸ IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.
⁹ School of Medicine, University of Cantabria, Santander, Spain.
¹⁰ Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
¹¹ Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
¹² Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
¹³ Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
¹⁴ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
¹⁵ Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
¹⁶ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
¹⁷ Department of Psychiatry, University of Marburg, Marburg, Germany.
¹⁸ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
¹⁹ Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
²⁰ Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
²¹ Interdisciplinary Lab for Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
²² Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
²³ Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.
²⁴ Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
²⁵ Institute of Medical Science, University of Toronto, Toronto, Canada.
²⁶ Centre for Addiction and Mental Health, Toronto, Canada.
²⁷ Department of Psychiatry, University of Toronto, Toronto, Canada.
²⁸ Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
²⁹ Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
³⁰ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 31424555
PMCID: PMC7043057
DOI: 10.1093/schbul/sbz067

Multicenter Study

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

Stefania Tognin et al. Schizophr Bull. 2020.

. 2020 Feb 26;46(2):432-441.

doi: 10.1093/schbul/sbz067.

Authors

Collaborators

PSYSCAN Consortium:
Philip McGuire, Stefania Tognin, Paolo Fusar-Poli, Matthew Kempton, Gemma Modinos, Kate Merritt, Andrea Mechelli, Paola Dazzan, George Gifford, Natalia Petros, Mathilde Antoniades, Andrea De Micheli, Sandra Vieira, Tom J Spencer, Cristina Scarpazza, Emily Hird, Rene Kahn, Arija Maat, Erika van Hell, Inge Winter, Wiepke Cahn, Hugo Schnack, Lieuwe de Haan, Dieuwke Siegmann, Jana Barkhof, Lotte Hendriks, Iris de Wit, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Esther Setien-Suero, Rosa Ayesa-Arriola, Paula Suarez-Pinilla, MariaLuz Ramirez-Bonilla, Victor Ortiz Garcia-de la Foz, Birte Glenthøj, Mikkel Erlang Sørensen, Karen Tangmose, Helle Schæbel, Brian Broberg, Egill Rostrup, Stephen Lawrie, Colm McDonald, Brian Hallahan, Dara Cannon, James McLoughlin, Martha Finnegan, Oliver Gruber, Therese van Amelsvoort, Danny Deckers, Machteld Marcelis, Claudia Vingerhoets, Celso Arango, Covadonga M Díaz-Caneja, Miriam Ayora, Joost Janssen, Roberto Rodríguez-Jiménez, Marina Díaz-Marsá, Tilo Kircher, Irina Falkenberg, Florian Bitsch, Philipp Berger, Jens Sommer, Kyeon Raab, Babette Jakobi, Barnaby Nelson, Patrick McGorry, Paul Amminger, Meredith McHugh, Silvana Galderisi, Armida Mucci, Paola Bucci, Giuseppe Piegari, Daria Pietrafesa, Alessia Nicita, Sara Patriarca, Rodrigo Bressan, André Zugman, Ary Gadelha, Graccielle Rodrigues da Cunha, Jun Soo Kwon, Kang I K Kevin Cho, Tae Young Lee, Minah Kim, Yoo Bin Kwak, Wu Jeong Hwang, Mark Weiser, Romina Mizrahi, Michael Kiang, Cory Gerritsen, Margaret Maheandiran, Sarah Ahmed, Ivana Prce, Jenny Lepock, Gabriele Sachs, Matthäus Willeit, Marzena Lenczowski, Ullrich Sauerzopf, Ana Weidenauer, Julia Furtner-Srajer, Matthias Kirschner, Anke Maatz, Achim Burrer, Philipp Stämpfli, Naemi Huber, Stefan Kaiser, Wolfram Kawohl, Michael Brammer, Jonathan Young, Edward Bullmore, Sarah Morgan

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
² Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, London, UK.
³ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
⁴ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
⁵ National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
⁶ Department Early Psychosis, Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
⁷ CIBERSAM, Department of Psychiatry, University Hospital Virgen del Rocío, Sevilla, Spain.
⁸ IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.
⁹ School of Medicine, University of Cantabria, Santander, Spain.
¹⁰ Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
¹¹ Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
¹² Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
¹³ Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
¹⁴ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
¹⁵ Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
¹⁶ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
¹⁷ Department of Psychiatry, University of Marburg, Marburg, Germany.
¹⁸ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
¹⁹ Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
²⁰ Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
²¹ Interdisciplinary Lab for Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
²² Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
²³ Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.
²⁴ Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
²⁵ Institute of Medical Science, University of Toronto, Toronto, Canada.
²⁶ Centre for Addiction and Mental Health, Toronto, Canada.
²⁷ Department of Psychiatry, University of Toronto, Toronto, Canada.
²⁸ Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
²⁹ Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
³⁰ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 31424555
PMCID: PMC7043057
DOI: 10.1093/schbul/sbz067

Erratum in

Corrigendum to: Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice.
[No authors listed] [No authors listed] Schizophr Bull. 2022 May 7;48(3):722. doi: 10.1093/schbul/sbz125. Schizophr Bull. 2022. PMID: 31930352 Free PMC article. No abstract available.

Abstract

In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures.

Keywords: MRI; PSYSCAN; clinical high risk of psychosis; first episode of psychosis; machine learning; neuroimaging; prediction; psychosis.

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Figures

**Fig. 1.**
(a) Organization structure of the PSYSCAN Consortium in WorkPackages (WP). (b) Timelines of the Work-Packages in PSYSCAN.

See this image and copyright information in PMC

References

1. Mechelli A, Riecher-Rössler A, Meisenzahl EM, et al. . Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study. Arch Gen Psychiatry. 2011;68(5):489–495. - PubMed
1. Pantelis C, Velakoulis D, McGorry PD, et al. . Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet. 2003;361(9354):281–288. - PubMed
1. Tognin S, Riecher-Rössler A, Meisenzahl EM, et al. . Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis. Psychol Med. 2014;44(3):489–498. - PMC - PubMed
1. Koutsouleris N, Riecher-Rossler A, Meisenzahl EM, et al. . Detecting the psychosis prodrome across high-risk populations using neuroanatomical biomarkers. Schizophr Bull. 2015;41(2):471–482. - PMC - PubMed
1. Smieskova R, Fusar-Poli P, Allen P, et al. . Neuroimaging predictors of transition to psychosis—a systematic review and meta-analysis. Neurosci Biobehav Rev. 2010;34(8):1207–1222. - PubMed

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Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

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Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

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