Volume of Distribution
- PMID: 31424864
- Bookshelf ID: NBK545280
Volume of Distribution
Excerpt
The volume of distribution (Vd) is a pharmacokinetic parameter representing an individual drug’s propensity to either remain in the plasma or redistribute to other tissue compartments. By definition, Vd is a proportionality constant that relates the total amount of drug in the body to the plasma concentration of the drug at a given time. The following equation can represent Vd:
Copyright © 2025, StatPearls Publishing LLC.
Conflict of interest statement
Sections
References
-
- Oie S. Drug distribution and binding. J Clin Pharmacol. 1986 Nov-Dec;26(8):583-6. - PubMed
-
- Smith DA, Beaumont K, Maurer TS, Di L. Volume of Distribution in Drug Design. J Med Chem. 2015 Aug 13;58(15):5691-8. - PubMed
-
- Toutain PL, Bousquet-Mélou A. Volumes of distribution. J Vet Pharmacol Ther. 2004 Dec;27(6):441-53. - PubMed
-
- Fan J, de Lannoy IA. Pharmacokinetics. Biochem Pharmacol. 2014 Jan 01;87(1):93-120. - PubMed
-
- Faed EM. Protein binding of drugs in plasma, interstitial fluid and tissues: effect on pharmacokinetics. Eur J Clin Pharmacol. 1981;21(1):77-81. - PubMed
Publication types
LinkOut - more resources
Full Text Sources